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If the enemy has Poison, apply 9 Poison.
Bubble Bubble is a highly efficient scaling tool that offers one of the best energy-to-poison ratios in the game, provided the target is already poisoned. It should be used as a follow-up to consistent poison sources to ensure its conditional effect triggers, rapidly accelerating the damage clock on high-HP enemies.
Snecko Skull
This relic increases every poison application by 1, which directly boosts the efficiency of Bubble Bubble's high-value stack. It ensures that every time you trigger the card's condition, you are maximizing the total poison output for a single energy point.
Noxious Fumes
Noxious Fumes provides a reliable, automatic poison application at the start of every turn to all enemies. This acts as a permanent primer, guaranteeing that Bubble Bubble will always be active and never a dead card in your hand.
Burst
Burst allows you to play your next skill twice, which effectively turns Bubble Bubble into an 18-poison application for very low cost. This combination provides the massive burst of damage over time needed to quickly take down bosses and elites.
Twisted Funnel
By applying poison to all enemies at the start of combat, this relic ensures Bubble Bubble is usable on the very first turn. This allows for immediate scaling without needing to wait for other poison-applying cards to appear in your opening draw.
Accelerant
Accelerant causes poison to trigger an additional time, doubling the effectiveness of the stacks applied by Bubble Bubble. Together, they create a lethal synergy where high-volume application meets high-frequency damage triggers.